P04.67 Assessments for prediction of bystander effect in HSV-tk/GCV gene therapy
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چکیده
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assessment of the effect of honey as a topical therapy for intra oral wound healing in rat.
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15 صفحه اولBystander or no bystander for gene directed enzyme prodrug therapy.
Gene directed enzyme prodrug therapy (GDEPT) of cancer aims to improve the selectivity of chemotherapy by gene transfer, thus enabling target cells to convert nontoxic prodrugs to cytotoxic drugs. A zone of cell kill around gene-modified cells due to transfer of toxic metabolites, known as the bystander effect, leads to tumour regression. Here we discuss the implications of either striving for ...
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The very deep knowledge acquired on the genetics and molecular biology of herpes simplex virus (HSV), has allowed the development of potential replication-competent and replication-defective vectors for several applications in human healthcare. These include delivery and expression of human genes to cells of the nervous systems, selective destruction of cancer cells, prophylaxis against infecti...
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Introduction: Chondrosarcoma is second to osteogenic sarcoma in frequency as a malignant tumor of bone. It is difficult to obtain wide surgical resection margins because of its location adjacent to neurovascular and visceral structures. Neither irradiation nor chemotherapy seems to be an effective treatment for chondrosarcoma; thus new protocols are needed. We reported gene therapy of chondrosa...
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a semi-empirical mathematical model for predicting physical part of ignition delay period in the combustion of direct - injection diesel engines with swirl is developed . this model based on a single droplet evaporation model . the governing equations , namely , equations of droplet motion , heat and mass transfer were solved simultaneously using a rung-kutta step by step unmerical method . the...
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ژورنال
عنوان ژورنال: Neuro-Oncology
سال: 2018
ISSN: 1522-8517,1523-5866
DOI: 10.1093/neuonc/noy139.301